Chromosomal Translocation


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In genetics , a chromosome translocation is a chromosome abnormality caused by rearrangement of parts between nonhomologous chromosomes . A gene fusion may be created when the translocation joins two otherwise-separated genes. It is detected on cytogenetics or a karyotype of affected cells . Translocations can be balanced (in an even exchange of material with no genetic information extra or missing, and ideally full functionality) or unbalanced (where the exchange of chromosome material is unequal resulting in extra or missing genes ). [1] [2]